Description

(3R,4S)-1-(2-Ethoxyethyl)-3-Methyl-2-Phenyl-Piperidin-4-Amine is a chiral piperidine derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where its specific stereochemistry is critical for biological activity. Pharmaceutical research and development teams, particularly those working in medicinal chemistry for central nervous system (CNS) and analgesic targets, are the primary industrial users of this high-value intermediate.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel analgesic and neuroactive drug candidates.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a building block requiring specific (3R,4S) stereochemistry for constructing complex molecular architectures.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals where high purity and defined chirality are essential.
• Reference Standard: Acts as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(3R,4S)-1-(2-Ethoxyethyl)-3-Methyl-2-Phenyl-Piperidin-4-Amine
CAS No.	125080-86-6
Molecular Formula	C16H26N2O
Molecular Weight	262.40 g/mol
Synonyms	1-(2-Ethoxyethyl)-3-methyl-2-phenyl-4-piperidinamine, (3R,4S)-; 4-Amino-1-(2-ethoxyethyl)-3-methyl-2-phenylpiperidine; 2-Phenyl-3-methyl-1-(2-ethoxyethyl)piperidin-4-amine; (3R-cis)-1-(2-Ethoxyethyl)-3-methyl-2-phenyl-4-piperidinamine; U-54494A (a common research code); A chiral 2,3-disubstituted piperidine derivative.
EINECS	Contact for details

Quality Control

Our (3R,4S)-1-(2-Ethoxyethyl)-3-Methyl-2-Phenyl-Piperidin-4-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3R,4S)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.