Description

1-Nicotinoyl-4-(3-Trifluoromethylphenyl)Piperazine Dihydrochloride is a high-purity, specialized organic compound with significant utility in advanced chemical synthesis. This compound serves as a critical pharmacological research intermediate, particularly valued for its structural features that are conducive to the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the discovery and process development of new therapeutic agents.

Application

• Pharmaceutical Research & Development (R&D): A key building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the process chemistry and scale-up synthesis of potential APIs, leveraging its piperazine and nicotinoyl motifs.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Biochemical Tool Compound: Utilized in in vitro assays to study receptor-ligand interactions and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis and process development.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Details
Product Name	1-Nicotinoyl-4-(3-Trifluoromethylphenyl)Piperazine Dihydrochloride
CAS No.	124444-72-0
Molecular Formula	C17H17F3N3O • 2HCl
Molecular Weight	424.26 g/mol (Free base: 336.34 g/mol)
Synonyms	1-(3-Trifluoromethylphenyl)-4-(nicotinoyl)piperazine dihydrochloride; 4-(3-Trifluoromethylphenyl)-1-(pyridine-3-carbonyl)piperazine dihydrochloride; N-(3-Trifluoromethylphenyl)-N'-(nicotinoyl)piperazine dihydrochloride; 1-Nicotinoyl-4-(3-trifluoromethylphenyl)piperazine HCl; 3-Trifluoromethylphenyl Nicotinoyl Piperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1-Nicotinoyl-4-(3-Trifluoromethylphenyl)Piperazine Dihydrochloride is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.