Description

1,25-Dihydroxy-16-Ene-Vitamin D3 is a synthetic analog of the active form of Vitamin D, specifically engineered with a double bond at the C-16 position. This structural modification is significant for research into vitamin D receptor (VDR) activity and metabolic pathways, offering a valuable tool for pharmaceutical development and biochemical studies. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for conditions related to calcium metabolism, cell differentiation, and immune modulation.

Application

• Pharmaceutical Reference Standard: Serves as a critical high-purity standard for analytical method development and quality control in drug manufacturing.
• Biochemical Research: Used as a key intermediate or probe in studying the structure-activity relationship (SAR) of Vitamin D analogs and VDR signaling mechanisms.
• Drug Discovery & Development: Acts as a precursor or active pharmaceutical ingredient (API) intermediate in the synthesis of next-generation Vitamin D-based therapies.
• Metabolic Studies: Employed in in-vitro and in-vivo research to investigate the metabolism and biological effects of modified Vitamin D compounds.

Basic Information

Product Name	1,25-Dihydroxy-16-Ene-Vitamin D3
CAS No.	124409-58-1
Molecular Formula	C₂₇H₄₀O₃
Molecular Weight	412.61 g/mol
Synonyms	1,25-Dihydroxy-16-ene-cholecalciferol; 16-ene-1,25-Dihydroxyvitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19),16-tetraene-1,3,25-triol; 1α,25-Dihydroxy-16-ene-vitamin D3; Calcitriol 16-ene analog; 16-Dehydrocalcitriol; 1,25(OH)₂-16-ene-D₃
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-16-Ene-Vitamin D3 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent research and development standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. This product is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.