Description

24,25,26-Trihydroxyvitamin D2 is a biologically active metabolite of vitamin D2 (ergocalciferol), representing a key intermediate in the calcitriol metabolic pathway. This compound is of significant value for research and development in endocrinology and metabolic disease studies. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity reference standards and analytical reagents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of vitamin D metabolites in drug formulations and biological samples via HPLC or LC-MS.
• Biochemical Research: Serves as a critical tool for investigating the metabolism, catabolism, and biological activity of vitamin D2 and its analogs in vitro and in vivo.
• Metabolic Pathway Studies: Essential for elucidating the specific roles of 24-hydroxylation in vitamin D signaling and calcium homeostasis.
• Diagnostic Kit Development: Employed in the calibration and validation of immunoassays and clinical diagnostic tests designed to measure vitamin D status.
• Nutraceutical Analysis: Acts as an analytical standard for quality control and assay verification in the manufacturing of vitamin D2-fortified foods and dietary supplements.

Basic Information

Product Name	24,25,26-Trihydroxyvitamin D2
CAS No.	123992-85-8
Molecular Formula	C28H44O5
Molecular Weight	460.65 g/mol
Synonyms	24R,25,26-Trihydroxyvitamin D2; 24R,25,26-Trihydroxyergocalciferol; (5Z,7E,22E)-(1S,3R,24R)-9,10-Secocholesta-5,7,10(19),22-tetraene-1,3,24,25,26-pentol; 24,25,26-Trihydroxyergocalciferol; Vitamin D2 metabolite 24,25,26-triol; 24,25,26-TriOH D2
EINECS	Contact for details

Quality Control

Our 24,25,26-Trihydroxyvitamin D2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to minimize moisture exposure. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.