Description

1,25-Dihydroxy-24-Trihomo-22-Ene-Vitamin D3 is a synthetic, biologically active vitamin D analog, representing a significant advancement in the field of secosteroid research and development. This compound matters for its role as a high-potency research tool and a key intermediate in the synthesis of novel vitamin D receptor (VDR) modulators. It is primarily needed by pharmaceutical R&D departments, academic research institutions, and fine chemical manufacturers focused on developing new therapeutic agents for conditions related to calcium metabolism, cell differentiation, and immune modulation.

Application

• Pharmaceutical Research & Development: A critical intermediate for synthesizing novel vitamin D analogs with potential therapeutic applications.
• Biochemical Research: Used as a high-affinity ligand in studies of the Vitamin D Receptor (VDR) to understand signaling pathways and gene regulation.
• Reference Standard: Serves as an analytical standard in HPLC and LC-MS methods for quality control and metabolic studies of vitamin D compounds.
• Preclinical Studies: Investigated for its biological activity in models related to osteoporosis, psoriasis, and certain cancers.
• Fine Chemical Synthesis: A building block for the custom synthesis of more complex secosteroids and hormone analogs.

Basic Information

Product Name	1,25-Dihydroxy-24-Trihomo-22-Ene-Vitamin D3
CAS No.	123963-52-0
Molecular Formula	C30H48O3
Molecular Weight	456.71 g/mol
Synonyms	1,25-Dihydroxy-24-trihomo-22-ene-cholecalciferol; 24-Trihomo-1,25-dihydroxy-22-ene-vitamin D3; 1α,25-Dihydroxy-24-trihomo-22-ene-vitamin D3; EB 1089 (common research code name); Seocalcitol (pharmaceutical development name); 22-Ene-24-trihomo-1,25-(OH)2D3; (5Z,7E,22E)-(1S,3R)-1,3-Dihydroxy-9,10-seco-24-trihomo-5,7,10(19),22-cholestatetraen-26-oic acid γ-lactone derivative (related IUPAC-style name).
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-24-Trihomo-22-Ene-Vitamin D3 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, purity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with client requirements for specific research or development projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is easily oxidized and light-sensitive; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solvent Residues (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.