Description

Insulin, 4-Fluorophenylalanine(A19)- CAS NO 123840-16-4 is a chemically modified insulin analog where the phenylalanine residue at position A19 is substituted with 4-fluorophenylalanine. This specific modification is of significant interest in biochemical and pharmaceutical research for studying insulin structure-function relationships, receptor binding, and metabolic stability. It serves as a critical tool compound for researchers and developers in the life sciences sector, particularly those focused on diabetes research, peptide engineering, and novel therapeutic discovery.

Application

• Biochemical Research: Used as a reference standard and probe to investigate the impact of fluorinated amino acid substitutions on peptide hormone activity and stability.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the binding epitopes of insulin to its receptor and understanding the role of specific aromatic residues.
• Metabolic Pathway Analysis: Employed in studies to compare the pharmacokinetics and degradation profiles of modified versus native insulin.
• Pharmaceutical Development: Acts as a precursor or model compound in the design and evaluation of novel insulin analogs with potentially improved therapeutic profiles.
• Academic & Industrial R&D: A key reagent for universities, research institutes, and biotech companies engaged in advanced peptide science and endocrinology.

Basic Information

Product Name	Insulin, 4-Fluorophenylalanine(A19)- CAS NO 123840-16-4
CAS No.	123840-16-4
Molecular Formula	C257H387N65O77S6 (Human Insulin basis with F substitution)
Molecular Weight	~5808 g/mol (approx.)
Synonyms	4-F-Phe(A19)-Insulin; Insulin (4-Fluorophenylalanine A19); A19-4-Fluorophenylalanine Insulin; Fluorinated Insulin Analog; [4-F-Phe(A19)]-Insulin; Insulin, 4-F-Phe(A19)-; 123840-16-4; Insulin modified at A19 position
EINECS	Contact for details

Quality Control

This research-grade biochemical is produced under strict quality control protocols. Each batch is characterized to ensure identity, purity, and consistency, supported by a comprehensive Certificate of Analysis (COA). Our quality system is designed to meet the exacting standards of pharmaceutical and academic research, ensuring reliable and reproducible results for your critical projects. Certificates of Analysis (COA) detailing purity, HPLC profile, and mass spec confirmation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Single Peak Purity (Analytical HPLC)	≥ 90%
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay (Data provided)
Solubility	Soluble in dilute acetic acid or suitable aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.