Description

cis-3-Methyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling precise control over the final product's three-dimensional structure. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of central nervous system (CNS) drugs and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its stereochemistry can influence biological activity.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for enantioselective reactions.
• Peptidomimetics & Bioactive Molecule Design: The protected carboxylic acid and piperidine ring make it a valuable component for designing peptide analogs and other bioactive compounds.
• Academic & Industrial R&D: Serves as a versatile starting material in medicinal chemistry programs and process chemistry development for scale-up.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	cis-3-Methyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	123834-09-3
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-tert-Butyl 2-methyl (3S,4R)-3-methylpiperidine-1,2-dicarboxylate; (3S,4R)-1-(tert-Butoxycarbonyl)-3-methylpiperidine-2-carboxylic acid; cis-1-Boc-3-methylpipecolic acid; (3S,4R)-1-Boc-3-methylpipecolic acid; cis-3-Methyl-1-Boc-pipecolic acid; (3S,4R)-3-Methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-2-carboxylic acid; BOC-3-methyl-DL-pipecolic acid (cis isomer)
EINECS	Contact for details

Quality Control

Our cis-3-Methyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.