Description

4-Methoxy-Piperidine-2-Carboxylic Acid is a versatile chiral piperidine derivative, a high-value building block prized for its role in synthesizing complex bioactive molecules. Its unique structure, featuring both a carboxylic acid and a methoxy-substituted piperidine ring, makes it a critical intermediate for pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to create novel compounds with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into peptide analogs to modify backbone structure, stability, and bioavailability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, stereochemically defined intermediates.

Basic Information

Product Name	4-Methoxy-Piperidine-2-Carboxylic Acid
CAS No.	123811-79-0
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	4-Methoxypipecolic Acid; (2S)-4-Methoxypiperidine-2-carboxylic acid; 4-Methoxy-2-piperidinecarboxylic Acid; L-4-Methoxypipecolic Acid; 4-Methoxy-DL-pipecolic Acid; 4-Methoxypipecolate; 2-Carboxy-4-methoxypiperidine
EINECS	Contact for details

Quality Control

Our 4-Methoxy-Piperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (enantiomeric excess)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.