Description

n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-4-Chlorobenzamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functionalized quinuclidine core. This compound is critical for research and development in medicinal chemistry, particularly for targeting neurological receptors. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential nicotinic acetylcholine receptor (nAChR) modulators and other neuroactive compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new candidates for central nervous system (CNS) disorders.
• Preclinical Development: Serves as a critical raw material for producing active pharmaceutical ingredients (APIs) in the early development pipeline.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies.

Basic Information

Product Name	n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-4-Chlorobenzamide
CAS No.	123464-89-1
Molecular Formula	C15H19ClN2O
Molecular Weight	278.78 g/mol
Synonyms	(R)-3-((4-Chlorobenzoyl)amino)quinuclidine; 4-Chloro-N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]benzamide; (R)-Quinuclidin-3-yl 4-chlorobenzamide; TC-2559; ABT-418 intermediate; (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-4-chlorobenzamide
EINECS	Contact for details

Quality Control

Our production of n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-4-Chlorobenzamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is characterized and released against comprehensive specifications, including chiral purity verification. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.