Description

5-Hydroxy Lornoxicam is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) Lornoxicam. This compound is of significant importance for research and development in pharmacology and analytical chemistry, particularly in studies related to drug metabolism, pharmacokinetics, and the development of new therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical service providers, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and reference standard purposes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Lornoxicam and its related substances in drug products and biological matrices.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and excretion profiles of Lornoxicam.
• Analytical Method Development: Serves as a key component in developing and validating high-performance liquid chromatography (HPLC), LC-MS, and other chromatographic methods for impurity profiling.
• API Manufacturing & QC: Employed in the quality control processes during the synthesis of Lornoxicam to monitor and control the levels of this specific impurity or degradation product.
• Pharmacological Studies: Used in research to understand the activity, toxicity, and overall pharmacological impact of Lornoxicam's metabolites.

Basic Information

Product Name	5-Hydroxy Lornoxicam
CAS No.	123252-96-0
Molecular Formula	C13H10ClN3O5S
Molecular Weight	355.75 g/mol
Synonyms	5-Hydroxy Lornoxicam; Lornoxicam Hydroxy Metabolite; 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-Dioxide; 5-Hydroxy-6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-Dioxide; Chlortenoxicam Hydroxy Metabolite; Ro 13-9297 metabolite
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Lornoxicam is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.