Description

2-Piperazineaceticacid,4-Hydroxy-3,6-Dioxo-,(S)-(9Ci) is a high-purity chiral piperazine derivative with significant synthetic utility. This compound serves as a critical advanced intermediate and building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules, particularly for applications in medicinal chemistry and drug discovery. The (S)-enantiomer offers precise stereochemical control for creating targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex molecular scaffolds with potential biological activity.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) requiring specific piperazine-based architectures.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Bioconjugation & Linker Chemistry: Potential use in developing antibody-drug conjugates (ADCs) or other bioconjugates due to its functional groups.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2-Piperazineaceticacid,4-Hydroxy-3,6-Dioxo-,(S)-(9Ci)
CAS No.	122556-80-3
Molecular Formula	C6H10N2O5
Molecular Weight	190.16 g/mol
Synonyms	(S)-4-Hydroxy-3,6-dioxopiperazine-2-acetic acid; (2S)-2-(4-Hydroxy-3,6-dioxopiperazin-2-yl)acetic acid; L-4-Hydroxy-3,6-dioxopiperazine-2-acetic acid; (S)-2-(4-Hydroxy-3,6-dioxopiperazin-2-yl)acetic acid; 2-Piperazineacetic acid, 4-hydroxy-3,6-dioxo-, (S)-; 122556-80-3; (S)-HODPA
EINECS	Contact for details

Quality Control

Our 2-Piperazineaceticacid,4-Hydroxy-3,6-Dioxo-,(S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.