Description

Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block and intermediate in the development of complex, biologically active molecules. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for applications in peptide mimetics, active pharmaceutical ingredient (API) synthesis, and medicinal chemistry research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other small molecule therapeutics.
• Peptidomimetic Chemistry: Used to construct constrained peptide analogs and scaffolds for drug discovery programs targeting GPCRs and enzymes.
• Active Pharmaceutical Ingredient (API) Development: Serves as a protected precursor in multi-step synthetic routes for complex APIs.
• Bioconjugation & Linker Chemistry: Utilized in the preparation of specialized linkers for antibody-drug conjugates (ADCs) and other targeted therapies.
• Asymmetric Synthesis: Acts as a source of chirality in catalytic and stoichiometric asymmetric transformations.
• Chemical Biology & Proteomics Research: Employed in the design and synthesis of activity-based probes and enzyme inhibitors for mechanistic studies.

Basic Information

Product Name	Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride
CAS No.	122323-88-0
Molecular Formula	C7H16Cl2N2O2
Molecular Weight	231.12 g/mol
Synonyms	Methyl 2-Piperazinecarboxylate Dihydrochloride; (S)-Piperazine-2-carboxylic Acid Methyl Ester Dihydrochloride; L-Pipecolic Acid Methyl Ester Dihydrochloride (related); Methyl Piperazine-2-carboxylate Dihydrochloride; 2-Piperazinecarboxylic Acid, Methyl Ester, Dihydrochloride; Methyl (S)-Piperazine-2-carboxylate Dihydrochloride; (S)-Methyl Piperazine-2-carboxylate Dihydrochloride; Methyl 2-Piperazinecarboxylate Hydrochloride (mixture)
EINECS	Contact for details

Quality Control

Our Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.