Description

Rosiglitazone is a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), primarily used as an active pharmaceutical ingredient (API). This compound is critical for the research and development of therapeutic agents targeting insulin resistance in type 2 diabetes. It is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in metabolic disorder studies and drug formulation.

Application

• Primary Active Pharmaceutical Ingredient (API) in anti-diabetic medications.
• Key reference standard for analytical method development and validation in quality control laboratories.
• Critical material for preclinical and clinical research on PPARγ-mediated pathways.
• Essential component in the formulation of combination therapies for metabolic syndrome.
• Used in biochemical research to study insulin sensitization and glucose homeostasis mechanisms.
• Important intermediate in the synthesis of novel thiazolidinedione derivatives for drug discovery programs.

Basic Information

Product Name	Rosiglitazone
CAS No.	122320-73-4
Molecular Formula	C18H19N3O3S
Molecular Weight	357.43 g/mol
Synonyms	5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; Avandia; BRL 49653; Rosiglitazone Maleate; (±)-Rosiglitazone; Rosiglitazone Base; PPARγ Agonist; Thiazolidinedione Derivative
EINECS	Contact for details

Quality Control

Our Rosiglitazone is manufactured under strict quality management systems, ensuring it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and related substances methods. Certificates of Analysis (COA) confirming compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.