Description

Englitazone CAS NO 122228-35-7 is a high-purity chemical compound belonging to the thiazolidinedione class, recognized for its role as a potent and selective PPARγ (peroxisome proliferator-activated receptor gamma) agonist. This compound is a critical intermediate and research tool in the development of novel therapeutic agents targeting metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in drug discovery programs for diabetes, inflammation, and related metabolic pathways.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of next-generation PPARγ modulators.
• Metabolic Disease Studies: Used as a potent pharmacological tool in preclinical research to investigate insulin sensitization, adipocyte differentiation, and glucose homeostasis mechanisms.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to evaluate compound libraries for PPARγ activity and selectivity.
• Academic Research: A vital reagent for universities and research institutes studying nuclear receptor biology, signal transduction, and the pathophysiology of type 2 diabetes.
• Process Chemistry & Scale-up: Used as a starting material or intermediate in process optimization and the cGMP-compliant manufacturing of clinical trial materials.

Basic Information

Product Name	Englitazone
CAS No.	122228-35-7
Molecular Formula	C18H18N2O3S
Molecular Weight	342.41 g/mol
Synonyms	Englitazone; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-[[4-[2-(5-Ethyl-2-pyridyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione; GW 1929; GW-1929; PPARγ Agonist GW1929; GW 1929 (PPARγ agonist)
EINECS	Contact for details

Quality Control

Our Englitazone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with in-house specifications. We support research requiring traceable and reliable materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.