Description

3,7,12,22-Tetrahydroxycholestanoic Acid is a multi-hydroxylated bile acid derivative, a key intermediate in the study of cholesterol metabolism and bile acid synthesis pathways. This compound is of significant value for its role as a precise biochemical tool in pharmaceutical research and development, particularly for investigating liver function and metabolic disorders. It is primarily needed by research institutions, pharmaceutical companies, and diagnostic manufacturers focused on endocrinology, hepatology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex bile acid analogs and potential therapeutic agents.
• Biochemical Research: Used as a reference standard and probe in studies of bile acid biosynthesis, transport, and receptor interactions.
• Metabolic Pathway Analysis: Essential for in vitro and in vivo research into cholesterol catabolism and related metabolic diseases.
• Diagnostic Development: Employed in the development and calibration of assays for detecting bile acid disorders and liver function tests.
• Enzymology Studies: Acts as a substrate for studying the activity of specific hydroxylases and other enzymes involved in steroid metabolism.

Basic Information

Product Name	3,7,12,22-Tetrahydroxycholestanoic Acid
CAS No.	121569-59-3
Molecular Formula	C27H46O6
Molecular Weight	466.66 g/mol
Synonyms	3α,7α,12α,22-Tetrahydroxy-5β-cholestan-26-oic Acid; (25R)-3α,7α,12α,22-Tetrahydroxy-5β-cholestan-26-oic Acid; 22-Tetrahydroxy-3,7,12-cholestanoic Acid; Tetrahydroxycholestanoic Acid; 3,7,12,22-THCA; A Key Bile Acid Intermediate; 5β-Cholestane-3α,7α,12α,22-tetrol-26-oic Acid
EINECS	Contact for details

Quality Control

Our 3,7,12,22-Tetrahydroxycholestanoic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.