Description

n-Ethyl-1,2-Dioleoylphosphatidylethanolamine is a synthetic, ethylated phospholipid derivative, a key building block in advanced lipid-based formulations. Its primary value lies in its ability to modify the surface properties and stability of lipid vesicles, making it a critical component for creating next-generation delivery systems. This high-purity phospholipid is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced cosmetics industries who require precise control over nanocarrier characteristics for drug delivery, gene therapy, and targeted cosmetic actives.

Application

• Lipid Nanoparticle (LNP) Formulation: As a structural and functional lipid component for mRNA, siRNA, and other nucleic acid delivery systems.
• Liposome & Niosome Stabilization: Used to engineer surface charge and enhance the colloidal stability and circulation time of vesicular carriers.
• Cationic Lipid Synthesis: Serves as a versatile precursor or intermediate for synthesizing novel cationic lipids for transfection.
• Biomimetic Membrane Research: Employed in model membrane studies to investigate lipid-protein interactions and membrane dynamics.
• Cosmetic Nanocarriers: Incorporated into high-performance cosmetic formulations for the stabilized delivery of vitamins, antioxidants, and other active ingredients.
• Diagnostic Agent Encapsulation: Used in the development of contrast agents and other diagnostic tools requiring stable lipid encapsulation.

Basic Information

Product Name	n-Ethyl-1,2-Dioleoylphosphatidylethanolamine
CAS No.	121521-33-3
Molecular Formula	C45H84NO8P
Molecular Weight	790.13 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phospho-N-ethylethanolamine; DOPE-N-Ethyl; N-Ethyl-DOPE; Ethyl-DOPE; N-Ethyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Phosphatidylethanolamine, N-ethyl-1,2-dioleoyl-; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl (2-aminoethyl)ethyl phosphate
EINECS	Contact for details

Quality Control

Our n-Ethyl-1,2-Dioleoylphosphatidylethanolamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, TLC for lipid profiling, and NMR for structural confirmation, to ensure it meets the stringent requirements for research and cGMP-guided formulation development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. For long-term storage, desiccate. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Lysophospholipid Content	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.