Description

1-Palmitoyl-2-(6-(Pyren-1-Yl)Hexanoyl)-Sn-Glycero-3-Phosphatidic Acid is a synthetic, fluorescently labeled phospholipid derivative, specifically a phosphatidic acid analog. This compound is of significant value as a highly specific molecular probe for studying lipid metabolism, membrane biophysics, and intracellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers engaged in advanced lipidomics and cell biology.

Application

• Biophysical Research: As a fluorescent tracer for investigating lipid bilayer dynamics, membrane fusion, and lipid-protein interactions using techniques like fluorescence spectroscopy and microscopy.
• Enzymology Studies: Serving as a specific substrate for assaying the activity of phospholipases, lipid kinases, and phosphatases involved in phosphatidic acid metabolism.
• Cell Signaling Research: Probing the role of phosphatidic acid as a lipid second messenger in cellular processes such as vesicle trafficking, cytoskeletal rearrangement, and mitogenic signaling.
• Lipidomics & Analytical Standards: Use as an internal standard or reference compound in mass spectrometry-based lipidomic profiling for accurate identification and quantification.
• Drug Discovery Screening: Employed in high-throughput screening assays to identify novel modulators of lipid metabolic enzymes or signaling pathways.
• Model Membrane Systems: Incorporation into liposomes and other artificial membrane systems to create fluorescently labeled models for targeted delivery or diagnostic studies.

Basic Information

Product Name	1-Palmitoyl-2-(6-(Pyren-1-Yl)Hexanoyl)-Sn-Glycero-3-Phosphatidic Acid
CAS No.	121496-64-8
Molecular Formula	C45H63O9P
Molecular Weight	778.95 g/mol
Synonyms	Pyrene-labeled Phosphatidic Acid; 1-Palmitoyl-2-(6-(1-Pyrenyl)hexanoyl)-sn-glycero-3-phosphate; PA(pyrene); 16:0-6:0 Pyrene PA; sn-3-Phosphatidic Acid (16:0-6:0(Pyrene)); Fluorescent Phosphatidic Acid; 1-Palmitoyl-2-(6-(Pyren-1-yl)hexanoyl)-sn-glycerol-3-phosphate; Pyrene-PA
EINECS	Contact for details

Quality Control

Our high-purity research-grade lipids are produced under stringent quality protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and functional integrity. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, methanol, DMSO
Fluorescence Properties	Excitation ~342 nm, Emission ~376 nm (in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.