Description

Piperazine, 1-(2,2-Difluoroacetyl)-4-Methyl- (9Ci) is a specialized fluorinated piperazine derivative, a high-value intermediate in advanced organic synthesis. Its core value lies in its unique difluoroacetyl functional group, which is critical for introducing fluorine atoms into target molecules to modulate their biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved pesticidal activity and environmental profile.
• Fluorine Chemistry Research: Serves as a versatile reagent for academic and industrial research exploring new fluorination methodologies and the structure-activity relationships of fluorinated compounds.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and performance materials.
• Ligand and Catalyst Development: Potential use in creating novel ligands or organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	Piperazine, 1-(2,2-Difluoroacetyl)-4-Methyl- (9Ci)
CAS No.	121412-30-4
Molecular Formula	C7H12F2N2O
Molecular Weight	178.18 g/mol
Synonyms	1-(2,2-Difluoroacetyl)-4-methylpiperazine; 4-Methyl-1-(2,2-difluoroacetyl)piperazine; N-(2,2-Difluoroacetyl)-4-methylpiperazine; 1-Methyl-4-(2,2-difluoroacetyl)piperazine; Difluoroacetyl-4-methylpiperazine; 121412-30-4 (CAS); 4-Methylpiperazine-1-carboxylic acid, 2,2-difluoro- (related form)
EINECS	Contact for details

Quality Control

Every batch of Piperazine, 1-(2,2-Difluoroacetyl)-4-Methyl- (9Ci) is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.