Description

Piperazine, 1-(Chlorodifluoroacetyl)- (9Ci) is a specialized fluorinated piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which incorporates both a piperazine ring and a reactive chlorodifluoroacetyl group, enabling precise chemical modifications. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoroacetyl moiety can enhance biological activity and stability.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: An important reagent for introducing fluorinated functional groups into complex molecules, a common strategy to improve metabolic stability and bioavailability.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke fine chemicals and advanced intermediates.

Basic Information

Product Name	Piperazine, 1-(Chlorodifluoroacetyl)- (9Ci)
CAS No.	121412-25-7
Molecular Formula	C6H9ClF2N2O
Molecular Weight	198.60 g/mol
Synonyms	1-(Chlorodifluoroacetyl)piperazine; N-(Chlorodifluoroacetyl)piperazine; Chlorodifluoroacetic acid piperazide; Piperazine, 1-(chlorodifluoroacetyl)-; 1-Piperazinecarboxylic acid, 2-chloro-2,2-difluoro-, hydrazide; 121412-25-7; AKOS025310584
EINECS	Contact for details

Quality Control

Our production of Piperazine, 1-(Chlorodifluoroacetyl)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.