Description

2-Chloro-4-Fluoro-5-Nitrobenzoyl Chloride is a high-purity, multi-functional aromatic acid chloride intermediate of significant importance in advanced organic synthesis. Its value lies in its reactive benzoyl chloride group and strategically placed halogen and nitro substituents, which make it a versatile building block for constructing complex molecules. This compound is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and nitro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the chloro-fluoro-nitro motif confers specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Polymer Modification: Employed to introduce functional aromatic groups into polymer chains to alter thermal or optical properties.
• Dyestuff & Pigment Intermediate: Utilized in the synthesis of complex, high-performance organic dyes and pigments.
• Cross-coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to its halogen substituents.
• Peptide Mimetics & Bioconjugation: The acyl chloride group is reactive towards amines, making it useful for creating amide bonds in peptide-like structures or bioconjugation linkers.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new chemical entities and reaction pathways.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Nitrobenzoyl Chloride
CAS No.	120890-66-6
Molecular Formula	C7H2Cl2FNO3
Molecular Weight	252.00 g/mol
Synonyms	5-Nitro-2-chloro-4-fluorobenzoyl chloride; 2-Chloro-4-fluoro-5-nitrobenzoic acid chloride; Benzoyl chloride, 2-chloro-4-fluoro-5-nitro-; 4-Fluoro-2-chloro-5-nitrobenzoyl chloride; 2-Chloro-4-fluoro-5-nitro-benzoic acid chloride; 2-Chloro-4-fluoro-5-nitrobenzoylchloride; 120890-66-6 (CAS); 2-Cl-4-F-5-NO2-BenzoylCl
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-Nitrobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.