Description

2-Propenoyl Chloride, 3-(1H-Indol-3-Yl)- is a specialized, high-value acryloyl chloride derivative featuring an indole moiety. This compound is a critical building block in advanced organic synthesis, prized for its reactivity as an acylating agent. It is primarily sought by R&D and production chemists in the pharmaceutical and agrochemical sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of biologically active indole-based compounds, including potential drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that incorporate the indole scaffold.
• Material Science Research: Employed in the creation of functional polymers and advanced materials where photoactive or electroactive indole units are required.
• Bioconjugation & Probe Development: Serves as a reactive handle for labeling biomolecules or synthesizing fluorescent probes and diagnostic agents.
• Academic & Contract Research: Essential reagent in university and CRO laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	2-Propenoyl Chloride, 3-(1H-Indol-3-Yl)-
CAS No.	120681-20-1
Molecular Formula	C11H8ClNO
Molecular Weight	205.64 g/mol
Synonyms	3-(1H-Indol-3-yl)acryloyl chloride; 3-Indolylacryloyl chloride; (E)-3-(1H-Indol-3-yl)acryloyl chloride; 3-(3-Indolyl)propenoyl chloride; 3-(Indol-3-yl)acrylic acid chloride; 120681-20-1; 3-(1H-Indol-3-yl)prop-2-enoyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Propenoyl Chloride, 3-(1H-Indol-3-Yl)- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed HPLC/GC and NMR data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.