Description

1H-Indole-2-Carbonylchloride,3-Methyl-(9Ci) is a versatile and reactive indole derivative, serving as a crucial acyl chloride intermediate in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex heterocyclic frameworks and amide bonds, which are fundamental to modern pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides, herbicides, and plant growth regulators with indole-based structures.
• Material Science Research: Acts as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its planar, conjugated indole core.
• Peptide Mimetics & Bioconjugation: Facilitates the introduction of the 3-methylindole-2-carbonyl moiety into peptides or biomolecules, creating analogs for biochemical studies.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for exploring new reaction pathways in heterocyclic chemistry.

Basic Information

Product Name	1H-Indole-2-Carbonylchloride,3-Methyl-(9Ci)
CAS No.	120608-03-9
Molecular Formula	C10H8ClNO
Molecular Weight	193.63 g/mol
Synonyms	3-Methyl-1H-indole-2-carbonyl chloride; 3-Methylindole-2-carbonyl chloride; 3-Methyl-1H-indole-2-carboxylic acid chloride; 2-(Chlorocarbonyl)-3-methylindole; 1H-Indole-2-carbonylchloride, 3-methyl-; 3-Methylindol-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole-2-Carbonylchloride,3-Methyl-(9Ci) is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.