Description

2-Chloro-6-Iodopyrazine is a versatile halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic positioning of halogen atoms on the pyrazine ring, enabling selective cross-coupling reactions and functional group transformations. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing pyrazine or pyridine cores for oncology and CNS applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogen sites for structure-activity relationship (SAR) studies.
• Material Science Building Block: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki, Stille, and Negishi couplings, where the iodine and chlorine atoms offer differential reactivity for sequential functionalization.
• Ligand and Catalyst Development: Utilized to synthesize novel nitrogen-containing ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Acts as a versatile handle for creating molecular probes and tags for studying biological systems.

Basic Information

Item	Details
Product Name	2-Chloro-6-Iodopyrazine
CAS No.	120531-35-3
Molecular Formula	C4H2ClIN2
Molecular Weight	240.43 g/mol
Synonyms	6-Chloro-3-Iodopyrazine; 2-Chloro-6-iodopyrazine; 3-Iodo-6-chloropyrazine; 6-Chloro-3-iodopyrazine; 2-Chloro-6-iodo-1,4-diazine; 2-Chloro-6-iodopyrazine (CAS 120531-35-3); Pyrazine, 2-chloro-6-iodo-
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Iodopyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.