Description

N,n-Dimethyl-2-[[(1R,2R,4R)-1,7,7-Trimethyl-2-Phenylbicyclo[2.2.1]Hept-2-Yl]Oxy]Ethanamine (2E)-2-Butenedioate is a high-purity, non-racemic chiral amine salt derived from a modified camphor skeleton. This compound matters as a sophisticated pharmaceutical intermediate and chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex, stereodefined molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis Catalyst/ Ligand: Utilized as a precursor for developing proprietary chiral ligands or organocatalysts for enantioselective transformations.
• Agrochemical Research: Serves as a building block for creating advanced, stereospecific pesticides and herbicides.
• Fine Chemical Synthesis: Employed in the multistep synthesis of complex fragrance molecules, flavors, and other high-value specialty chemicals.
• Academic & Industrial R&D: Used in methodological research for developing new synthetic routes and studying stereochemical outcomes.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	N,n-Dimethyl-2-[[(1R,2R,4R)-1,7,7-Trimethyl-2-Phenylbicyclo[2.2.1]Hept-2-Yl]Oxy]Ethanamine (2E)-2-Butenedioate
CAS No.	120444-74-8
Molecular Formula	C24H35NO5
Molecular Weight	417.54 g/mol
Synonyms	Fumarate salt of (1R,2R,4R)-2-[(2-Dimethylaminoethoxy)]-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptane; (1R,2R,4R)-2-[(2-Dimethylaminoethoxy)]-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptane fumarate; Dexoxadrol fumarate; Dioxadrol fumarate (stereoisomer); (+)-2-[(2-Dimethylaminoethoxy)methyl]-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptane fumarate; NSC 526063 (as fumarate); Chiral camphor-derived amine fumarate
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-2-[[(1R,2R,4R)-1,7,7-Trimethyl-2-Phenylbicyclo[2.2.1]Hept-2-Yl]Oxy]Ethanamine (2E)-2-Butenedioate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure identity, strength, and composition. Certificates of Analysis (COA) detailing specifications such as enantiomeric excess (ee), assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.