Description

Ho-Peg6-Ch2Cooh CAS NO 120394-66-3 is a functionalized polyethylene glycol derivative, specifically a hexaethylene glycol-based linker terminated with a carboxylic acid group. This bifunctional molecule is essential for creating stable, water-soluble conjugates in advanced pharmaceutical and biotechnological applications. It is primarily used by researchers and manufacturers in drug discovery, bioconjugation, and the development of antibody-drug conjugates (ADCs) and peptide therapeutics.

Application

• Bioconjugation Linker: A key reagent for covalently attaching drugs, dyes, or other functional molecules to proteins, peptides, and antibodies.
• Antibody-Drug Conjugate (ADC) Development: Serves as a hydrophilic spacer in ADC constructs, improving solubility and pharmacokinetic profiles.
• Peptide Modification: Used to introduce PEG chains (PEGylation) onto peptides to enhance stability, reduce immunogenicity, and prolong circulation time.
• Cross-linking Agent: Facilitates the formation of stable amide bonds between amine-containing and carboxyl-containing biomolecules.
• Polymer Chemistry: Acts as a functional monomer or macroinitiator for synthesizing tailored, biocompatible polymers.
• Diagnostic Reagent Synthesis: Employed in the preparation of fluorescent probes and imaging agents for in vitro and in vivo diagnostics.
• Surface Functionalization: Used to modify nanoparticles and other material surfaces with carboxylic acid groups for further biomolecule attachment.
• Research & Development: A versatile tool compound in life science R&D for exploring new therapeutic modalities and delivery systems.

Basic Information

Item	Details
Product Name	Ho-Peg6-Ch2Cooh CAS NO 120394-66-3
CAS No.	120394-66-3
Molecular Formula	C15H28O9
Molecular Weight	352.38 g/mol
Synonyms	6-((2-(2-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)acetic Acid; HO-PEG6-CH2COOH; Hexaethylene glycol monoacetic acid; 2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic Acid; PEG6 Acid; 17-Hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oic Acid; Carboxy-PEG6-alcohol; Acetic acid, 2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-
EINECS	Contact for details

Quality Control

Our Ho-Peg6-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.