Description

n-(1-Deoxyfructosyl)Amphotericin B is a chemically modified derivative of the potent polyene macrolide antifungal agent, Amphotericin B. This derivative is significant for its potential to alter the pharmacokinetic profile and reduce the inherent toxicity associated with the parent compound, while retaining or modifying its biological activity. It is primarily of interest to research scientists and pharmaceutical developers in the life sciences, antifungal drug discovery, and advanced pharmaceutical formulation sectors.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel, less toxic antifungal agents.
• Antifungal Mechanism Studies: Used in biochemical and microbiological research to investigate structure-activity relationships (SAR) of polyene antibiotics.
• Drug Delivery System Development: Explored in the formulation of targeted delivery systems, such as liposomal or nanoparticle carriers, to enhance therapeutic efficacy.
• Bioconjugation Chemistry: Serves as a model compound in studies focusing on the glycosylation or other chemical modifications of complex natural products.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	n-(1-Deoxyfructosyl)Amphotericin B
CAS No.	119829-29-7
Molecular Formula	C47H73NO17
Molecular Weight	924.09 g/mol
Synonyms	Amphotericin B N-(1-deoxy-D-fructos-1-yl) derivative; 1-Deoxy-1-(amphotericin B amino)-D-fructose; Amphotericin B fructosylamine; N-(1-Deoxyfructosyl)amphotericin B; Amphotericin B sugar derivative
EINECS	Contact for details

Quality Control

Our n-(1-Deoxyfructosyl)Amphotericin B is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider keeping the material under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.