Description

4-(5-Aminopyridin-2-Yl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine-pyridine derivative that serves as a critical building block in modern organic synthesis. This compound is essential for research and development chemists requiring a versatile intermediate with orthogonal protecting groups for selective functionalization. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in kinase inhibitor and receptor modulator programs.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially in oncology and CNS therapeutic areas.
• Kinase Inhibitor Development: Used as a core scaffold or linker in the design and synthesis of protein kinase inhibitors.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Peptidomimetics & PROTACs: Integral component in the construction of peptidomimetic structures and Proteolysis-Targeting Chimeras (PROTACs).
• Material Science Research: Potential precursor for functionalized polymers or ligands in catalytic systems.

Basic Information

Product Name	4-(5-Aminopyridin-2-Yl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	119285-07-3
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate; 1-Boc-4-(5-amino-2-pyridyl)piperazine; 4-(5-Amino-2-pyridinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-5-amine; 1-(tert-Butoxycarbonyl)-4-(5-aminopyridin-2-yl)piperazine; Boc-4-(5-amino-2-pyridyl)piperazine; 119285-07-3
EINECS	Contact for details

Quality Control

Our 4-(5-Aminopyridin-2-Yl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.