Description

(S)-1-Cbz-5-Oxo-Piperidine-2-Carboxylic Acid Methyl Ester is a high-purity chiral piperidine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling the development of targeted therapeutics. This intermediate is essential for research and production teams in the pharmaceutical and biotechnology sectors, particularly those focused on protease inhibitors, neurological agents, and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in protease inhibitor programs.
• API Development: Used in the research and scale-up production of Active Pharmaceutical Ingredients (APIs) requiring a constrained (S)-configured amino acid backbone.
• Peptidomimetics: Serves as a crucial component in the design and synthesis of peptidomimetic compounds to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic processes to introduce chirality into more complex molecular architectures.
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies for various therapeutic targets.
• Custom Synthesis: A foundational block for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	(S)-1-Cbz-5-Oxo-Piperidine-2-Carboxylic Acid Methyl Ester
CAS No.	117836-13-2
Molecular Formula	C15H17NO5
Molecular Weight	291.30 g/mol
Synonyms	(2S)-1-[(Benzyloxy)carbonyl]-5-oxopiperidine-2-carboxylic acid methyl ester; Methyl (2S)-1-[(benzyloxy)carbonyl]-5-oxopiperidine-2-carboxylate; (S)-1-Cbz-5-oxo-2-piperidinecarboxylic acid methyl ester; (S)-Methyl 1-(benzyloxycarbonyl)-5-oxopiperidine-2-carboxylate; (S)-1-Cbz-5-oxopipecolic acid methyl ester; (S)-1-Cbz-5-oxo-piperidine-2-carboxylic acid methyl ester; (S)-1-Cbz-5-oxo-piperidine-2-carboxylate methyl ester
EINECS	Contact for details

Quality Control

Our (S)-1-Cbz-5-Oxo-Piperidine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.