Description

5S-Hydroxy-6R-(S-(2-Oxo-3-Thiopropionyl))-7E,9E,11Z,14Z-Eicosatetraenoic Acid CAS NO 117675-20-4 is a specialized eicosanoid derivative, a key synthetic intermediate in advanced biochemical research. This compound is valued for its role in studying and modulating leukotriene and prostaglandin pathways, which are critical in inflammatory and immune responses. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on developing novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel leukotriene analogs and anti-inflammatory drug candidates.
• Biochemical Research: Used as a reference standard and probe in studies of arachidonic acid metabolism, eicosanoid signaling, and lipid mediator pathways.
• Cell Biology Studies: Applied in in vitro assays to investigate the role of specific eicosanoids in cellular processes like chemotaxis and inflammation.
• Fine Chemical Synthesis: Serves as a high-value chiral synthon for the preparation of complex, biologically active molecules in medicinal chemistry.
• Reference Material: Provides a characterized standard for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	5S-Hydroxy-6R-(S-(2-Oxo-3-Thiopropionyl))-7E,9E,11Z,14Z-Eicosatetraenoic Acid
CAS No.	117675-20-4
Molecular Formula	C23H34O6S
Molecular Weight	438.58 g/mol
Synonyms	5(S)-Hydroxy-6(R)-(S-(2-oxo-3-thiopropionyl))-7E,9E,11Z,14Z-eicosatetraenoic acid; 5-HETE-S-Lactone Thioester Derivative; 5(S)-HETE-6(R)-S-Lactone Thioester; Leukotriene A4 Thioester Analog; 5-Hydroxyeicosatetraenoic Acid Thioester; (5S,6R)-5-Hydroxy-6-[(2-oxo-3-thiolanyl)carbonyl]oxyicosa-7E,9E,11Z,14Z-tetraenoic Acid; Eicosatetraenoic Acid, 5-hydroxy-6-[(2-oxo-3-thienyl)acetyl]oxy-, (5S,6R,7E,9E,11Z,14Z)-
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment, supporting compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.