Description

12-Hydroxy-5,8,14-Eicosatrienoic Acid is a specialized hydroxy fatty acid derivative of eicosatrienoic acid, serving as a key intermediate in the synthesis of bioactive lipid mediators. This compound is valued for its role in biochemical research and the development of novel therapeutic agents targeting inflammatory pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors.

Application

• Biochemical Research: Used as a reference standard and precursor in studies of lipoxygenase and cytochrome P450 pathways.
• Pharmaceutical Intermediates: Serves as a critical building block for the synthesis of pro-resolving lipid mediators and other bioactive molecules.
• Inflammation & Immunology Studies: Applied in vitro and in vivo research to investigate the role of hydroxy-eicosatrienoic acids (HETEs) in cellular signaling.
• Analytical Standard: Employed as a high-purity calibrant in LC-MS and HPLC methods for lipidomics analysis.
• Specialty Chemical Synthesis: Utilized in the production of labeled compounds (e.g., deuterated or 13C-labeled) for tracer studies.

Basic Information

Product Name	12-Hydroxy-5,8,14-Eicosatrienoic Acid
CAS No.	117346-20-0
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	12-HETE (5,8,14); 12-Hydroxy-5,8,14-eicosatrienoic acid; 12-Hydroxyicosa-5,8,14-trienoic acid; 12(S)-HETE (5,8,14); 12-Hydroxy-5,8,14-icosatrienoic acid; (12S)-Hydroxy-(5Z,8Z,14Z)-eicosatrienoic acid; 12-Hydroxy-5Z,8Z,14Z-eicosatrienoic acid
EINECS	Contact for details

Quality Control

Our 12-Hydroxy-5,8,14-Eicosatrienoic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a dry, cool, and well-ventilated area. Allow the product to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.