Description

25-Hydroxy-26,27-Dimethylvitamin D3 is a synthetic analog of the active metabolite of vitamin D3, designed for enhanced metabolic stability and targeted biological activity. This compound is crucial for advanced research and development in endocrinology and metabolic bone disease studies, offering a valuable tool for investigating vitamin D receptor (VDR) signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of high-purity reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quality control and assay development of vitamin D analogs and related pharmaceutical products.
• Biochemical Research: Used as a key intermediate or active compound in metabolic studies, cell signaling research, and investigations into calcium and phosphate homeostasis.
• Drug Discovery & Development: Acts as a lead compound or a synthetic precursor in the development of novel therapeutics for osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Analytical Chemistry: Employed as a high-purity standard for method development and validation in analytical techniques such as HPLC, LC-MS, and UV spectroscopy.
• Nutritional Science Research: Utilized in studies exploring the structure-activity relationships (SAR) of vitamin D metabolites and their role in human health.

Basic Information

Product Name	25-Hydroxy-26,27-Dimethylvitamin D3
CAS No.	116925-40-7
Molecular Formula	C₂₉H₄₆O₂
Molecular Weight	426.68 g/mol
Synonyms	1α,25-Dihydroxy-26,27-dimethylcholcalciferol; 25-Hydroxy-26,27-dimethylcholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3β,25-diol, 26,27-dimethyl-; 26,27-Dimethyl-25-hydroxyvitamin D3; Ro 23-6019
EINECS	Contact for details

Quality Control

Our 25-Hydroxy-26,27-Dimethylvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C (refrigerated) or as specified on the certificate of analysis. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.