Description

4-(2-Hydroxyethyl)-Piperazine-1-Carboxylic Acid Amide is a versatile piperazine derivative with a hydroxyl-functionalized side chain. This compound is valued for its bifunctional nature, serving as a key building block in the synthesis of complex molecules and as a modifier in specialty formulations. It is primarily sought by the pharmaceutical, agrochemical, and specialty chemical industries for research, development, and production processes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and as a component in linker chemistry for drug conjugates.
• Agrochemical Synthesis: Used in the development and production of advanced herbicides, fungicides, and plant growth regulators, where its structure contributes to biological activity and solubility.
• Polymer & Resin Modifier: Acts as a cross-linking agent or chain extender in polyurethane and epoxy resin systems, enhancing mechanical properties and thermal stability.
• Bioconjugation & Linker Chemistry: Employed in the design of probes, diagnostics, and antibody-drug conjugates (ADCs) due to its reactive hydroxyl and amide groups.
• Corrosion Inhibitor Formulation: A component in specialty chemical formulations for industrial water treatment and metal surface protection.
• Research & Development: Serves as a valuable scaffold in medicinal chemistry for high-throughput screening and the discovery of new bioactive compounds.

Basic Information

Product Name	4-(2-Hydroxyethyl)-Piperazine-1-Carboxylic Acid Amide
CAS No.	116882-73-6
Molecular Formula	C7H15N3O2
Molecular Weight	173.22 g/mol
Synonyms	1-Piperazineacetamide, N-(2-hydroxyethyl)-; 2-(4-Carbamoylpiperazin-1-yl)ethanol; N-(2-Hydroxyethyl)piperazine-1-carboxamide; 1-Carbamoyl-4-(2-hydroxyethyl)piperazine; HE-Pip-CONH2; 4-(2-Hydroxyethyl)piperazine-1-carboxamide; 2-(Piperazin-1-yl)acetamide, N-(2-hydroxyethyl)- derivative
EINECS	Contact for details

Quality Control

Our 4-(2-Hydroxyethyl)-Piperazine-1-Carboxylic Acid Amide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and ISO standards for industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in water, methanol, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.