Description

1,3-Dioxolane-4-Carbonyl Chloride, 2,2-Dimethyl-, (4S)- (9Ci) is a high-value, chiral building block and key synthetic intermediate. This compound is critical for introducing the (S)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid moiety into complex molecular architectures. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries. The product is supplied with a focus on consistent purity and reliable synthesis to support advanced organic transformations.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and neurological disorders.
• Chiral Auxiliary Synthesis: Used to construct chiral auxiliaries and ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products that contain protected glyceraldehyde or similar motifs.
• Peptidomimetics & Prodrug Development: Employed to create modified peptide backbones and prodrug linkers, enhancing metabolic stability and bioavailability.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing novel polymers with specific stereochemical properties.

Basic Information

Product Name	1,3-Dioxolane-4-Carbonyl Chloride, 2,2-Dimethyl-, (4S)- (9Ci)
CAS No.	116561-26-3
Molecular Formula	C6H9ClO3
Molecular Weight	164.59 g/mol
Synonyms	(4S)-2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride; (S)-(-)-2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride; (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid chloride; L-Glyceric acid cyclic acetonide chloride; (S)-(-)-Acetonide glyceric acid chloride; (4S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid chloride; (S)-Acetonide glycerol acid chloride
EINECS	Contact for details

Quality Control

Our production of 1,3-Dioxolane-4-Carbonyl Chloride, 2,2-Dimethyl-, (4S)- adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A detailed Certificate of Analysis (COA) providing purity, enantiomeric excess, and impurity profiles is supplied with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.