Description

Combretastatin B-3 is a potent natural stilbenoid compound originally isolated from the South African bush willow, *Combretum caffrum*. This molecule serves as a crucial advanced pharmaceutical intermediate and reference standard in modern drug discovery and development pipelines. It is primarily sought after by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and vascular biology.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of more complex Combretastatin analogs and derivatives for preclinical and clinical studies.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in the production of related active pharmaceutical ingredients (APIs).
• Biological Research: Valuable tool compound for studying tubulin polymerization inhibition, anti-angiogenic mechanisms, and vascular disrupting agent (VDA) activity.
• Lead Compound Optimization: Serves as a structural scaffold for medicinal chemistry programs aimed at improving pharmacokinetic properties and therapeutic efficacy.
• Academic & Contract Research: Utilized in university and CRO settings for investigating novel cancer therapeutics and cellular signaling pathways.

Basic Information

Product Name	Combretastatin B-3
CAS No.	116518-76-4
Molecular Formula	C17H18O5
Molecular Weight	302.32 g/mol
Synonyms	(Z)-3,4',5-Trimethoxy-3'-hydroxystilbene; 3'-Hydroxy-3,4,5-trimethoxystilbene; (Z)-Combretastatin B3; (Z)-3'-Hydroxy-3,4,5-trimethoxystilbene; 3,4',5-Trimethoxy-3'-hydroxy-(Z)-stilbene; NSC 365794
EINECS	Contact for details

Quality Control

Our Combretastatin B-3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.