Description

12(S)-Hepe is a specialized, high-purity eicosapentaenoic acid (EPA) derivative, specifically the 12(S)-hydroperoxy form, with the CAS registry number 116180-17-7. This compound serves as a critical bioactive lipid mediator and a valuable reference standard in biochemical research. It is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and life science sectors who require precise, high-quality intermediates for studying inflammation pathways, lipid metabolism, and for the development of analytical methods.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in liquid chromatography (HPLC, LC-MS) for the quantification and identification of oxylipins and eicosanoids.
• Pharmaceutical R&D: Acts as a key intermediate or probe in the research and development of novel therapeutics targeting inflammatory and metabolic disorders.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the role of specific hydroxyeicosatetraenoic acids (HETEs) and related lipid mediators in cellular signaling pathways.
• Nutraceutical Analysis: Serves as an analytical standard for quality control and metabolic studies in the ω-3 fatty acid and dietary supplement industry.
• Enzymology Substrate: Utilized as a substrate for studying the activity and kinetics of lipoxygenase (LOX) and other related enzymes.

Basic Information

Product Name	12(S)-Hepe
CAS No.	116180-17-7
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	12(S)-HpEPE; (12S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z,17Z-pentaenoic Acid; 12(S)-HPEPE; 12S-HpEPE; 12(S)-HpETE; 12S-Hydroperoxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic Acid; 12(S)-Hydroperoxyeicosapentaenoic Acid
EINECS	Contact for details

Quality Control

Every batch of 12(S)-Hepe is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.