Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoric Acid Sodium Salt is a high-purity synthetic phospholipid derivative, specifically a sodium salt of phosphatidic acid with oleoyl chains. This compound is a critical building block and functional excipient in advanced pharmaceutical and biotechnology applications, valued for its anionic charge and lipid bilayer-forming properties. It is essential for researchers and manufacturers in the life sciences sector developing liposomal drug delivery systems, lipid nanoparticles (LNPs), and advanced cell culture media.

Application

• Liposomal Drug Delivery: A key anionic lipid component for formulating stable, pH-sensitive, or targeted liposomes for encapsulating therapeutic agents.
• mRNA-LNP Formulations: Used as a helper lipid or structural component in lipid nanoparticle (LNP) systems for mRNA vaccines and therapies.
• Biomimetic Membrane Research: Serves as a model anionic phospholipid for studying membrane biophysics, protein-lipid interactions, and membrane fusion processes.
• Cell Culture & Transfection Reagents: A component in complex lipid mixtures used to create lipofectamine-type reagents for efficient cellular transfection.
• Diagnostic Assays: Employed in the development of biosensors and diagnostic kits where a stable anionic lipid surface is required.
• Cosmetic Actives Carrier: Functions in high-end cosmetic formulations to create nanocarriers for the sustained delivery of active ingredients.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoric Acid Sodium Salt
CAS No.	116004-31-0
Molecular Formula	C39H72NaO8P
Molecular Weight	722.96 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phosphate sodium salt; PA(18:1/18:1) Sodium Salt; Sodium 1,2-dioleoyl-sn-glycero-3-phosphate; DOPA Sodium Salt; Phosphatidic Acid (18:1) Sodium Salt; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphate sodium salt; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl hydrogen phosphate sodium salt
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoric Acid Sodium Salt is manufactured under strict quality systems suitable for pharmaceutical research and GMP applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurities. We ensure compliance with relevant ICH guidelines for stability and impurity profiling. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
1-Palmitoyl-2-oleoyl isomer	≤ 1.0%
Lysophospholipid Content	≤ 0.5%
Solvent Residues	Meets ICH limits
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.