Description

1',3'-Bis[1,2-Dioleoyl-Sn-Glycero-3-Phospho]-Sn-Glycerol (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a sodium salt of a cardiolipin analog. This compound is critical for creating stable, biomimetic lipid bilayers and vesicles, serving as a fundamental building block in advanced life science research and formulation development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise, reproducible lipid components for drug delivery systems, membrane studies, and biosensor development. CAS NO 115404-77-8.

Application

• Liposome & Nanoparticle Formulation: A key component for constructing stable, anionic liposomes used in targeted drug delivery and vaccine adjuvants.
• Biomimetic Membrane Research: Used to create model membranes that mimic mitochondrial or bacterial inner membranes for studying protein-lipid interactions and membrane dynamics.
• Diagnostic Reagent Development: Employed in the formulation of reagents for immunoassays, including latex agglutination tests and biosensors.
• Cell Culture & Transfection: Acts as a lipid component in transfection reagents to enhance nucleic acid delivery into cells.
• Surface Chemistry & Coatings: Used to create supported lipid bilayers (SLBs) on sensor chips and other substrates for biophysical analysis.
• Reference Standard: Serves as a high-purity analytical standard in quality control and method development for lipid analysis.

Basic Information

Product Name	1',3'-Bis[1,2-Dioleoyl-Sn-Glycero-3-Phospho]-Sn-Glycerol (Sodium Salt)
CAS No.	115404-77-8
Molecular Formula	C81H144Na2O17P2
Molecular Weight	1490.93 g/mol
Synonyms	Cardiolipin (18:1) Sodium Salt; Tetraoleoyl Cardiolipin Sodium Salt; 1,3-Bis(1,2-dioleoyl-sn-glycero-3-phospho)-sn-glycerol Sodium Salt; CL(18:1)4 Na Salt; TOCL Na Salt; (3-sn-Phosphatidyl)Glycerol Sodium Salt; 1',3'-Bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol Sodium Salt
EINECS	Contact for details

Quality Control

Our 1',3'-Bis[1,2-Dioleoyl-Sn-Glycero-3-Phospho]-Sn-Glycerol (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, TLC for lipid profile, and NMR for structural confirmation, to ensure identity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Production can adhere to cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Once opened, the material should be used promptly. Aliquot into single-use vials to minimize repeated exposure to air and moisture. Store away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus Content)	≥ 98% of theoretical
Solubility	Soluble in chloroform, methanol, ethanol; forms dispersions in aqueous buffers
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.