Description

Dg-Me Phosphonamidite CAS NO 115131-08-3 is a specialized phosphoramidite monomer, a critical building block in the automated synthesis of oligonucleotides. This compound matters for its high reactivity and selectivity, enabling the efficient and precise construction of DNA and RNA sequences. It is primarily needed by manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors for applications in antisense therapy, PCR primers, and genetic research.

Application

• Key monomer for the solid-phase synthesis of oligonucleotides (DNA/RNA).
• Manufacturing of primers and probes for polymerase chain reaction (PCR) and sequencing.
• Production of antisense oligonucleotides for therapeutic applications.
• Synthesis of siRNA (small interfering RNA) for gene silencing research.
• Development of aptamers for diagnostic and sensor technologies.
• Research and development of novel nucleic acid-based therapeutics.
• Scale-up production for Good Manufacturing Practice (GMP) grade active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Dg-Me Phosphonamidite
CAS No.	115131-08-3
Molecular Formula	C33H41N6O5P
Molecular Weight	632.70 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dG(ib)-CE Phosphoramidite; 2'-Deoxyguanosine, N2-isobutyryl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(2-cyanoethyl) N,N-diisopropylphosphoramidite; Guanosine Phosphoramidite, DMT protected; dG(ib) Phosphoramidite; N-Isobutyryl-2'-deoxyguanosine Phosphoramidite; DNA Synthesis Reagent
EINECS	Contact for details

Quality Control

Our Dg-Me Phosphonamidite is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity verification, to ensure it meets the high standards required for oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance in GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opened to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.