Description

Cyclo(L-Leu-trans-4-Hydroxy-L-Pro) CAS NO 115006-86-5 is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), derived from the amino acids leucine and hydroxyproline. This compound is of significant interest in pharmaceutical research and development due to its role as a key structural motif and potential pharmacophore. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications in drug discovery, peptide chemistry, and as a building block for more complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel therapeutic agents and peptide-based drugs.
• Biochemical Research: Used as a standard or reference compound in studies of peptide conformation, stability, and biological activity.
• Drug Discovery: Explored as a core scaffold in medicinal chemistry for developing enzyme inhibitors or receptor modulators.
• Peptide Mimetics: Acts as a stable, conformationally restricted template to mimic bioactive peptide sequences.
• Cosmetic Peptide Synthesis: Potential use as a precursor in the development of anti-aging or skin-conditioning peptide ingredients.

Basic Information

Product Name	Cyclo(L-Leu-trans-4-Hydroxy-L-Pro)
CAS No.	115006-86-5
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	Cyclo(leucyl-hydroxyprolyl); Cyclo(L-Leucyl-trans-4-hydroxy-L-prolyl); (3S,6S,9aS)-3-Isobutyl-6-(hydroxymethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; L-Leucyl-trans-4-hydroxy-L-proline diketopiperazine; c(Leu-Hyp); Diketopiperazine (Leu-Hyp); 115006-86-5; Cyclo(L-Leu-Hyp)
EINECS	Contact for details

Quality Control

Our Cyclo(L-Leu-trans-4-Hydroxy-L-Pro) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.