Description

1-Piperazineaceticacid,-α-,3-Dimethyl-2-Oxo-,[S-(R*,R*)]-(9Ci) is a high-purity, stereochemically defined chiral piperazine derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and cardiovascular systems.
• API Development: Used in research and process development for new chemical entities (NCEs) requiring a specific stereochemical configuration.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating chiral ligands used in asymmetric catalysis.
• Bioconjugation Chemistry: Utilized as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	1-Piperazineaceticacid,-α-,3-Dimethyl-2-Oxo-,[S-(R*,R*)]-(9Ci)
CAS No.	114966-97-1
Molecular Formula	C8H14N2O3
Molecular Weight	186.21 g/mol
Synonyms	(2S,5S)-1-(Carboxymethyl)-5-methyl-2-piperazineacetic acid; (2S,5S)-1-Carboxymethyl-5-methylpiperazine-2-acetic acid; (2S,5S)-5-Methyl-1-(carboxymethyl)piperazine-2-acetic acid; L-threo-5-Methylpiperazine-2-acetic acid, N-carboxymethyl-; (S,S)-5-Methyl-1-(carboxymethyl)piperazine-2-acetic acid; (2S,5S)-1-(Carboxymethyl)-5-methylpiperazine-2-acetic acid; 1-Piperazineacetic acid, α,3-dimethyl-2-oxo-, [S-(R*,R*)]-
EINECS	Contact for details

Quality Control

Our 1-Piperazineaceticacid,-α-,3-Dimethyl-2-Oxo-,[S-(R*,R*)]-(9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.