Description

(3S,4S)-Ethyl 3-Azido-4-Hydroxypiperidine-1-Carboxylate is a high-purity, chiral piperidine derivative that serves as a critical building block in modern synthetic organic chemistry. This compound matters for its role as a versatile intermediate in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on new drug candidates, especially in the areas of antiviral, neurological, and oncological therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in the construction of complex molecular scaffolds for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for potential new drugs.
• Antiviral Agent Synthesis: A potential precursor in the synthesis of compounds targeting viral proteases or replication mechanisms.
• Neurological Drug Development: Used in the preparation of molecules designed to interact with central nervous system receptors.
• Chemical Biology Probes: The azido group allows for bioorthogonal "click chemistry" applications, such as labeling or conjugation in probe development.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or template in stereoselective synthesis due to its defined (3S,4S) configuration.

Basic Information

Product Name	(3S,4S)-Ethyl 3-Azido-4-Hydroxypiperidine-1-Carboxylate
CAS No.	114870-50-7
Molecular Formula	C8H14N4O3
Molecular Weight	214.22 g/mol
Synonyms	Ethyl (3S,4S)-3-azido-4-hydroxypiperidine-1-carboxylate; 1-Carbethoxy-3-azido-4-hydroxypiperidine, (3S,4S)-; (3S,4S)-1-(Ethoxycarbonyl)-3-azido-4-piperidinol; 3-Azido-4-hydroxypiperidine-1-carboxylic acid ethyl ester; 1-Piperidinecarboxylic acid, 3-azido-4-hydroxy-, ethyl ester, (3S,4S)-; (3S,4S)-3-Azido-4-hydroxy-1-piperidinecarboxylic acid ethyl ester; Azidohydroxypiperidine carboxylate; AHP-Carboxylate
EINECS	Contact for details

Quality Control

Our (3S,4S)-Ethyl 3-Azido-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes rigorous analytical testing, including chiral purity verification by HPLC, to confirm identity, strength, and quality. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.