Description

14,15-Dehydro Leukotriene B4 is a specialized leukotriene analog and a key biochemical tool used in the study of inflammatory and immune response pathways. This compound matters for researchers and pharmaceutical developers as it serves as a crucial reference standard and a potent agonist for investigating leukotriene receptor biology and signaling cascades. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in drug discovery for inflammatory diseases such as asthma, arthritis, and psoriasis.

Application

• Biochemical Research: Used as a high-purity reference standard in analytical methods like HPLC and LC-MS for quantifying leukotriene metabolites.
• Pharmacological Studies: Acts as a potent agonist in in vitro and in vivo assays to study the BLT1 and BLT2 leukotriene receptors.
• Drug Discovery & Development: A critical tool for screening and validating novel anti-inflammatory drug candidates targeting the leukotriene pathway.
• Cell Signaling Research: Employed to elucidate intracellular signaling mechanisms, including calcium mobilization and neutrophil chemotaxis.
• Academic & Institutional Labs: Essential for basic research into the role of leukotrienes in inflammation, allergy, and immune system regulation.

Basic Information

Product Name	14,15-Dehydro Leukotriene B4
CAS No.	114616-11-4
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	14,15-Dehydro-LTB4; (5S,12R)-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid; 5(S),12(R)-DiHETE; 14,15-didehydro-Leukotriene B4; δ¹⁴-Leukotriene B4; 14,15-Dehydro LTB4; LTB4 analog
EINECS	Contact for details

Quality Control

Our 14,15-Dehydro Leukotriene B4 is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation by spectroscopic methods (NMR, MS), and verification of biological activity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Once opened, it is recommended to reseal the container under inert gas and return it to the recommended cold storage immediately.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.