Description

2-Nor-1,3-Seco-1,25-Dihydroxyvitamin D3 is a synthetic, biologically active vitamin D analog and a key intermediate in the synthesis of advanced calcitriol derivatives. This compound is crucial for pharmaceutical research and development, particularly in creating novel therapeutics targeting vitamin D receptor pathways. It is primarily utilized by R&D chemists and manufacturers in the pharmaceutical and biotechnology sectors for developing treatments related to bone metabolism, immune modulation, and cellular differentiation.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced vitamin D analogs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in biochemical and pharmacological research to study vitamin D receptor (VDR) activation and signaling mechanisms.
• Drug Discovery: Serves as a precursor in the development of new therapeutic agents for osteoporosis, psoriasis, and certain cancers.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Studies: Utilized in in vitro and in vivo studies to investigate the role of seco-steroids in calcium homeostasis and cell regulation.

Basic Information

Product Name	2-Nor-1,3-Seco-1,25-Dihydroxyvitamin D3
CAS No.	113490-37-2
Molecular Formula	C₂₆H₄₂O₃
Molecular Weight	402.61 g/mol
Synonyms	1,25-Dihydroxy-2-nor-1,3-seco-vitamin D3; 2-Nor-1,3-seco-1α,25-Dihydroxycholecalciferol; 1α,25-Dihydroxy-2-nor-1,3-seco-9,10-secocholesta-5,7,10(19)-trien-3β-ol; 2-Nor-1,3-seco Calcitriol derivative; Vitamin D3 analog intermediate; Seco-steroid intermediate; 1,25-(OH)₂-2-nor-1,3-seco-D3
EINECS	Contact for details

Quality Control

Our 2-Nor-1,3-Seco-1,25-Dihydroxyvitamin D3 is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.