Description

4-(4-Aminophenyl)-Piperidine is a versatile aromatic amine-piperidine hybrid compound that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a primary aromatic amine and a secondary aliphatic amine, makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of central nervous system (CNS) active drugs, receptor antagonists, and various bioactive molecules.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Monomer or cross-linking agent for producing high-performance polyamides, polyimides, and epoxy curing agents.
• Ligand & Catalyst Preparation: Used to synthesize chelating ligands for metal catalysts in asymmetric synthesis and coupling reactions.
• Dye & Pigment Manufacturing: Intermediate for azo dyes and other colorants requiring a stable aromatic amine component.
• Research & Development: Valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-(4-Aminophenyl)-Piperidine
CAS No.	113310-52-4
Molecular Formula	C11H16N2
Molecular Weight	176.26 g/mol
Synonyms	4-(4-Aminophenyl)piperidine; 4-Piperidin-4-ylaniline; 4-Amino-4'-piperidinyl-1,1'-biphenyl (incorrect but common); 4-(4-Aminophenyl)piperidine hydrochloride (salt form); 4-(p-Aminophenyl)piperidine; 1-(4-Aminophenyl)piperidine; 4-(4-Aminophenyl)piperidine free base; CAS 113310-52-4
EINECS	Contact for details

Quality Control

Our 4-(4-Aminophenyl)-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can supply material compliant with ICH Q7 guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.