Description

24R-Calcipotriol is a synthetic vitamin D3 analog, specifically the 24R epimer of calcipotriol, with the CAS registry number 112827-99-3. This compound is a critical active pharmaceutical ingredient (API) valued for its potent regulatory effects on cell proliferation and differentiation. It is primarily required by pharmaceutical manufacturers and research institutions developing topical treatments for chronic skin conditions, leveraging its targeted biological activity.

Application

• Pharmaceutical API: Primary active ingredient in topical ointments, creams, and solutions for the treatment of psoriasis and other hyperproliferative skin disorders.
• Dermatological Research: Key reference standard and investigational compound in studies of vitamin D receptor (VDR) pathways and skin cell modulation.
• Combination Therapies: Used in fixed-dose combination products, often with corticosteroids, for enhanced efficacy in managing plaque psoriasis.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Drug Discovery: A lead structure for the research and development of new vitamin D analogs with improved therapeutic profiles.

Basic Information

Product Name	24R-Calcipotriol
CAS No.	112827-99-3
Molecular Formula	C₂₇H₄₀O₃
Molecular Weight	412.60 g/mol
Synonyms	Calcipotriol 24R Epimer; (24R)-Calcipotriol; (5Z,7E,22E,24R)-9,10-Secochola-5,7,10(19),22-tetraene-1α,3β,24-triol; MC 903R; 24-epi-Calcipotriol; 24R-epi-Calcipotriol; 1α,24(R)-Dihydroxyvitamin D3-22-ene-26,23-lactone
EINECS	Contact for details

Quality Control

Our 24R-Calcipotriol is manufactured under strict quality management systems. Each batch is tested to meet high-purity pharmaceutical standards, with comprehensive analysis including identity, purity, and impurity profiling. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications aligned with ICH guidelines. We support cGMP requirements for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.