Description

(3S,5S,6R)-tert-Butyl 3-Bromo-2-Oxo-5,6-Diphenylmorpholine-4-Carboxylate is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex pharmaceutical molecules, particularly those with morpholine or piperidine scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries who require precise stereochemistry for the synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce the morpholine-2-one moiety with defined stereochemistry at multiple centers.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs targeting various disease pathways.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, stereospecific pesticides and herbicides.
• Chemical Biology Probes: Useful for creating labeled or modified compounds to study biological mechanisms and protein interactions.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex target molecules.

Basic Information

Product Name	(3S,5S,6R)-tert-Butyl 3-Bromo-2-Oxo-5,6-Diphenylmorpholine-4-Carboxylate
CAS No.	112741-51-2
Molecular Formula	C21H22BrNO4
Molecular Weight	432.31 g/mol
Synonyms	tert-Butyl (3S,5S,6R)-3-bromo-2-oxo-5,6-diphenylmorpholine-4-carboxylate; 4-(tert-Butoxycarbonyl)-3-bromo-5,6-diphenylmorpholin-2-one; 3-Bromo-5,6-diphenyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholin-2-one; (3S,5S,6R)-3-Bromo-5,6-diphenyl-4-(tert-butoxycarbonyl)morpholin-2-one; 4-Boc-3-bromo-5,6-diphenylmorpholin-2-one; (3S,5S,6R)-3-Bromo-5,6-diphenyl-4-((tert-butoxycarbonyl)morpholin-2-one; 112741-51-2
EINECS	Contact for details

Quality Control

Our (3S,5S,6R)-tert-Butyl 3-Bromo-2-Oxo-5,6-Diphenylmorpholine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.