Description

1-Boc-4-Bromoacetyl-1,4-Diazepane is a high-purity, protected heterocyclic building block of significant importance in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of complex pharmaceutical molecules, particularly those targeting the central nervous system. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates and bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drug candidates.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing and synthesizing peptidomimetics and macrocyclic compounds.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and protein-ligand interactions.
• Library Synthesis for Drug Discovery: A valuable building block for generating diverse compound libraries in high-throughput screening campaigns.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	1-Boc-4-Bromoacetyl-1,4-Diazepane
CAS No.	112257-14-4
Molecular Formula	C₁₂H₂₁BrN₂O₃
Molecular Weight	321.21 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-(bromoacetyl)-1,4-diazepane; 4-(Bromoacetyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester; 1-Boc-4-(bromoacetyl)homopiperazine; tert-Butyl 4-(bromoacetyl)-1,4-diazepane-1-carboxylate; 1,4-Diazepane-1-carboxylic acid, 4-(bromoacetyl)-, 1,1-dimethylethyl ester; Boc-4-bromoacetylhomopiperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Bromoacetyl-1,4-Diazepane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, ensuring reliable performance in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.