Description

Nafenopin-Coenzyme A CAS NO 112195-81-0 is a high-purity biochemical reagent, specifically the coenzyme A conjugate of the peroxisome proliferator-activated receptor alpha (PPARα) agonist nafenopin. This compound is a critical tool for researchers investigating lipid metabolism, fatty acid oxidation, and the molecular mechanisms of PPARα activation. It is primarily utilized in advanced biochemical research, pharmaceutical development, and metabolic studies where precise molecular interactions are required.

Application

• Biochemical Research: Used as a key substrate or ligand in enzymatic assays and studies of PPARα receptor binding and activation pathways.
• Metabolic Disease Studies: Essential for in vitro research on dyslipidemia, non-alcoholic fatty liver disease (NAFLD), and other disorders of lipid metabolism.
• Pharmaceutical Development: Serves as a reference standard or intermediate in the discovery and development of novel PPARα-targeting therapeutics.
• Enzymology: Employed in studies of acyl-CoA synthetases and transferases to understand the conjugation and metabolic fate of fibrate drugs.
• Cell Signaling Pathways: A vital tool for elucidating the downstream effects of PPARα activation on gene expression related to energy homeostasis.
• Toxicology & Safety Assessment: Used in mechanistic studies to understand the long-term effects and safety profile of peroxisome proliferators.

Basic Information

Product Name	Nafenopin-Coenzyme A
CAS No.	112195-81-0
Molecular Formula	C₃₈H₆₂N₇O₁₉P₃S
Molecular Weight	1058.92 g/mol
Synonyms	Nafenopin Coenzyme A; Nafenopin-CoA; 2-Methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy]propanoic acid Coenzyme A conjugate; CoA conjugate of Nafenopin; Nafenopin Acyl-CoA; PPARα Agonist CoA Conjugate; Nafenopinoyl-Coenzyme A
EINECS	Contact for details

Quality Control

Every batch of Nafenopin-Coenzyme A is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with high-purity biochemical standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.