Description

(5R,15S)-Dihydroxy-(6E,8Z,11Z,13E)-Eicosatetraenoic Acid is a specialized dihydroxy fatty acid derivative, specifically a dihydroxyeicosatetraenoic acid (diHETE) regioisomer, with the CAS number 111990-31-9. This compound is a significant bioactive lipid mediator involved in critical inflammatory and resolution pathways, making it a valuable tool for biochemical and pharmacological research. It is primarily sought by researchers and developers in the life sciences sector for studying eicosanoid signaling, inflammation models, and the development of novel therapeutic agents.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for the identification and quantification of lipid mediators in complex biological samples via LC-MS/MS or HPLC.
• Inflammation & Immunology Studies: A critical tool for investigating the role of specific lipoxygenase (LOX) pathway metabolites in cellular signaling, immune response modulation, and the resolution of inflammation.
• Pharmaceutical R&D: Serves as a key intermediate or reference compound in the discovery and development of novel anti-inflammatory drugs and modulators of eicosanoid pathways.
• Cell Biology & Signal Transduction: Applied in cell culture studies to elucidate receptor-ligand interactions and downstream effects of specific diHETE isomers on cellular functions.
• Metabolomics & Lipidomics: An essential component in targeted metabolomic panels for comprehensive mapping of oxylipin profiles in disease states versus healthy controls.
• Enzyme Activity Assays: Used as a substrate or product in assays to study the activity and inhibition of enzymes like lipoxygenases and cytochrome P450s.

Basic Information

Product Name	(5R,15S)-Dihydroxy-(6E,8Z,11Z,13E)-Eicosatetraenoic Acid
CAS No.	111990-31-9
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	(5R,15S)-diHETE; 5(R),15(S)-Dihydroxyeicosa-6E,8Z,11Z,13E-tetraenoic Acid; 5R,15S-DiHETE; (5R,15S)-DiHETE; 5,15-DiHETE isomer; Lipoxin/Resolvin Pathway Intermediate; 5,15-Dihydroxy-6,8,11,13-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our (5R,15S)-Dihydroxy-(6E,8Z,11Z,13E)-Eicosatetraenoic Acid is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via MS and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.