Description

Retinoic Acid,4,5-Didehdro-5,6-Dihydro,9-cis- is a specialized synthetic retinoid derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its precise stereochemistry and structure make it a critical building block for research and development in targeted therapies. This high-purity compound is essential for pharmaceutical manufacturers and advanced research institutions focused on dermatology, oncology, and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel retinoid-based drugs targeting nuclear receptors.
• Biochemical Research: Used as a reference standard and active agent in studies of cell differentiation, proliferation, and apoptosis.
• Dermatological R&D: Investigated for the development of next-generation topical treatments for acne, psoriasis, and photoaging.
• Oncology Research: Employed in preclinical studies exploring retinoid pathways in cancer cell lines.
• Metabolic Disorder Studies: Utilized in research related to lipid metabolism and metabolic syndrome.
• Cosmeceutical Development: Serves as a high-potency ingredient in advanced skincare formulation research.

Basic Information

Product Name	Retinoic Acid,4,5-Didehdro-5,6-Dihydro,9-cis-
CAS No.	111957-72-3
Molecular Formula	C20H26O2
Molecular Weight	298.42 g/mol
Synonyms	9-cis-4,5-Didehydro-5,6-dihydroretinoic Acid; 9-cis-Didehydroretinoic Acid; 9cDDRA; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic Acid; 9-cis-DDRA; 4,5-Didehydro-5,6-dihydro-9-cis-retinoic Acid; Alitretinoin Impurity; Retinoid Intermediate
EINECS	Contact for details

Quality Control

Our Retinoic Acid,4,5-Didehdro-5,6-Dihydro,9-cis- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. Due to its sensitivity to light and oxidation, the container should only be opened in a controlled environment and material should be used promptly.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residue (GC)	Meets ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.